Sexual dimorphism in COVID-19: potential medical and public well being implications

1. Grabek A Dolfi B Klein B Jian-Motamedi F Chaboissier MC Schedl A The grownup…

Sexual dimorphism in COVID-19: potential medical and public well being implications
  • 1.
    • Grabek A
    • Dolfi B
    • Klein B
    • Jian-Motamedi F
    • Chaboissier MC
    • Schedl A

    The grownup adrenal cortex undergoes fast tissue renewal in a sex-specific method.

    Cell Stem Cell. 2019; 25: 290-296.e2

  • 2.

    Sexual dimorphism in immunometabolism and autoimmunity: influence on personalised drugs.

    Autoimmun Rev. 2021; 20102775

  • 3.

    Intercourse-specific variations in hypertension and related heart problems.

    Nat Rev Nephrol. 2018; 14: 185-201

  • 4.
    • Alwani M
    • Yassin A
    • Al-Zoubi RM
    • et al.

    Intercourse-based variations in severity and mortality in COVID-19.

    Rev Med Virol. 2021; 31e2223

  • 5.
    • Chen N
    • Zhou M
    • Dong X
    • et al.

    Epidemiological and medical traits of 99 circumstances of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive research.

    Lancet. 2020; 395: 507-513

  • 6.
    • Zhao S
    • Cao P
    • Chong MKC
    • et al.

    COVID-19 and gender-specific distinction: evaluation of public surveillance knowledge in Hong Kong and Shenzhen, China, from January 10 to February 15, 2020.

    Infect Management Hosp Epidemiol. 2020; 41: 750-751

  • 7.

    The intercourse, gender and COVID-19 mission.

  • 8.
    • Geldsetzer P
    • Mukama T
    • Jawad N
    • Riffe T
    • Rogers A
    • Sudharsanan N

    Intercourse variations within the mortality fee for coronavirus illness 2019 in comparison with different causes of loss of life.

    medRxiv. 2021; ()

  • 9.
    • Chakravarty D
    • Nair SS
    • Hammouda N
    • et al.

    Intercourse variations in SARS-CoV-2 an infection charges and the potential hyperlink to prostate most cancers.

    Commun Biol. 2020; 3: 374

  • 10.

    Intercourse variations for fasting ranges of glucose and insulin: increasing our understanding.

    Nat Rev Endocrinol. 2021; 17: 131

  • 11.
    • Lagou V
    • Mägi R
    • Hottenga J-J
    • et al.

    Intercourse-dimorphic genetic results and novel loci for fasting glucose and insulin variability.

    Nat Commun. 2021; 12: 1-18

  • 12.
    • Tramunt B
    • Smati S
    • Coudol S
    • et al.

    Intercourse disparities in COVID-19 outcomes of inpatients with diabetes: insights from the CORONADO research.

    Eur J Endocrinol. 2021; 185: 299-311

  • 13.
    • McGurnaghan SJ
    • Weir A
    • Bishop J
    • et al.

    Dangers of and threat elements for COVID-19 illness in folks with diabetes: a cohort research of the full inhabitants of Scotland.

    Lancet Diabetes Endocrinol. 2021; 9: 82-93

  • 14.
    • Iorga A
    • Cunningham CM
    • Moazeni S
    • Ruffenach G
    • Umar S
    • Eghbali M

    The protecting function of estrogen and estrogen receptors in heart problems and the controversial use of estrogen remedy.

    Biol Intercourse Differ. 2017; 8: 33

  • 15.
    • Veldhuis JD
    • Sharma A
    • Roelfsema F

    Age-dependent and gender-dependent regulation of hypothalamic-adrenocorticotropic-adrenal axis.

    Endocrinol Metab Clin North Am. 2013; 42: 201-225

  • 16.
    • Amur S
    • Parekh A
    • Mummaneni P

    Intercourse variations and genomics in autoimmune ailments.

    J Autoimmun. 2012; 38: J254-J265

  • 17.
    • Umiker BR
    • Andersson S
    • Fernandez L
    • et al.

    Dosage of X-linked Toll-like receptor 8 determines gender variations within the improvement of systemic lupus erythematosus.

    Eur J Immunol. 2014; 44: 1503-1516

  • 18.
    • O’Driscoll DN
    • De Santi C
    • McKiernan PJ
    • McEneaney V
    • Molloy EJ
    • Greene CM

    Expression of X-linked Toll-like receptor 4 signaling genes in feminine vs. male neonates.

    Pediatr Res. 2017; 81: 831-837

  • 19.
    • Schurz H
    • Salie M
    • Tromp G
    • Hoal EG
    • Kinnear CJ
    • Möller M

    The X chromosome and sex-specific results in infectious illness susceptibility.

    Hum Genomics. 2019; 13: 2

  • 20.
    • Berghöfer B
    • Frommer T
    • Haley G
    • Fink L
    • Bein G
    • Hackstein H

    TLR7 ligands induce greater IFN-alpha manufacturing in females.

    J Immunol. 2006; 177: 2088-2096

  • 21.

    Construction of the SARS-CoV-2 spike receptor-binding area sure to the ACE2 receptor.

    Nature. 2020; 581: 215-220

  • 22.
    • Gagliardi MC
    • Tieri P
    • Ortona E
    • Ruggieri A

    ACE2 expression and intercourse disparity in COVID-19.

    Cell Demise Discov. 2020; 6: 37

  • 23.

    X-linked ailments: inclined females.

    Genet Med. 2020; 22: 1156-1174

  • 24.
    • Karlberg J
    • Chong DS
    • Lai WY

    Do males have the next case fatality fee of extreme acute respiratory syndrome than girls do?.

    Am J Epidemiol. 2004; 159: 229-231

  • 25.
    • Barthel A
    • Mohanraj Ok
    • Biener AM
    • Bornstein SR

    Metabolic syndrome and COVID-19: endocrine-immune vascular interactions form the medical course.

    Endocrinology. 2020; 161bqaa131

  • 26.
    • Dotan A
    • Muller S
    • Kanduc D
    • David P
    • Halpert G
    • Shoenfeld Y

    The SARS-CoV-2 as an instrumental set off of autoimmunity.

    Autoimmun Rev. 2021; 20102792

  • 27.
    • Steenblock C
    • Schwarz PEH
    • Ludwig B
    • et al.

    COVID-19 and metabolic illness: mechanisms and medical administration.

    Lancet Diabetes Endocrinol. 2021; 9: 786-798

  • 28.
    • Elzinga SE
    • Savelieff MG
    • O’Brien PD
    • Mendelson FE
    • Hayes JM
    • Feldman EL

    Intercourse variations in insulin resistance, however not peripheral neuropathy, in a diet-induced prediabetes mouse mannequin.

    Dis Mannequin Mech. 2021; 14dmm048909

  • 29.
    • Broussard JL
    • Perreault L
    • Macias E
    • et al.

    Intercourse variations in insulin sensitivity are associated to muscle tissue acylcarnitine however not subcellular lipid distribution.

    Weight problems (Silver Spring). 2021; 29: 550-561

  • 30.
    • Sheng L
    • Jena PK
    • Hu Y
    • Wan YY

    Age-specific microbiota in altering host inflammatory and metabolic signaling in addition to metabolome based mostly on the intercourse.

    Hepatobiliary Surg Nutr. 2021; 10: 31-48

  • 31.
    • Goossens GH
    • Jocken JWE
    • Blaak EE

    Sexual dimorphism in cardiometabolic well being: the function of adipose tissue, muscle and liver.

    Nat Rev Endocrinol. 2021; 17: 47-66

  • 32.
    • Karere GM
    • Cox LA
    • Bishop AC
    • et al.

    Intercourse variations in microRNA expression and cardiometabolic threat elements in hispanic adolescents with weight problems.

    J Pediatr. 2021; 235: 138-143.e5

  • 33.

    Intercourse variations in immune responses.

    Nat Rev Immunol. 2016; 16: 626-638

  • 34.

    Weight problems as a predictor for a poor prognosis of COVID-19: a scientific evaluation.

    Diabetes Metab Syndr. 2020; 14: 655-659

  • 35.
    • Petersen A
    • Bressem Ok
    • Albrecht J
    • et al.

    The function of visceral adiposity within the severity of COVID-19: Highlights from a unicenter cross-sectional pilot research in Germany.

    Metabolism. 2020; 110154317

  • 36.
    • Földi M
    • Farkas N
    • Kiss S
    • et al.

    Visceral adiposity elevates the chance of crucial situation in COVID-19: a scientific evaluation and meta-analysis.

    Weight problems (Silver Spring). 2021; 29: 521-528

  • 37.
    • Ishikawa A
    • Wada T
    • Nishimura S
    • et al.

    Estrogen regulates sex-specific localization of regulatory T cells in adipose tissue of overweight feminine mice.

    PLoS One. 2020; 15e0230885

  • 38.
    • Camporez JP
    • Lyu Ok
    • Goldberg EL
    • et al.

    Anti-inflammatory results of oestrogen mediate the sexual dimorphic response to lipid-induced insulin resistance.

    J Physiol. 2019; 597: 3885-3903

  • 39.
    • Varghese M
    • Griffin C
    • McKernan Ok
    • et al.

    Intercourse variations in inflammatory responses to adipose tissue lipolysis in diet-induced weight problems.

    Endocrinology. 2019; 160: 293-312

  • 40.
    • Takahashi T
    • Ellingson MK
    • Wong P
    • et al.

    Intercourse variations in immune responses that underlie COVID-19 illness outcomes.

    Nature. 2020; 588: 315-320

  • 41.
    • Chen Y
    • Klein SL
    • Garibaldi BT
    • et al.

    Growing old in COVID-19: vulnerability, immunity and intervention.

    Ageing Res Rev. 2021; 65101205

  • 42.
    • Márquez EJ
    • Chung CH
    • Marches R
    • et al.

    Sexual-dimorphism in human immune system getting old.

    Nat Commun. 2020; 11: 751

  • 43.

    The physiological mechanisms of the sex-based distinction in outcomes of COVID19 an infection.

    Entrance Physiol. 2021; 12627260

  • 44.
    • Mauvais-Jarvis F
    • Klein SL
    • Levin ER

    Estradiol, progesterone, immunomodulation, and COVID-19 outcomes.

    Endocrinology. 2020; 161bqaa127

  • 45.

    Estradiol induced alterations of the immune system–I. Enhancement of IgM manufacturing.

    Int J Immunopharmacol. 1985; 7: 207-213

  • 46.
    • Qi F
    • Qian S
    • Zhang S
    • Zhang Z

    Single cell RNA sequencing of 13 human tissues establish cell sorts and receptors of human coronaviruses.

    Biochem Biophys Res Commun. 2020; 526: 135-140

  • 47.
    • Subbarayan Ok
    • Ulagappan Ok
    • Wickenhauser C
    • Bachmann M
    • Seliger B

    Immune interplay map of human SARS-CoV-2 goal genes: implications for therapeutic avenues.

    Entrance Immunol. 2021; 12597399

  • 48.

    Dipeptidyl peptidase 4 (DPP4) inhibitor and end result from coronavirus illness 2019 (COVID-19) in diabetic sufferers: a scientific evaluation, meta-analysis, and meta-regression.

    J Diabetes Metab Disord. 2021; 20: 1-8

  • 49.
    • Khunti Ok
    • Knighton P
    • Zaccardi F
    • et al.

    Prescription of glucose-lowering therapies and threat of COVID-19 mortality in folks with kind 2 diabetes: a nationwide observational research in England.

    Lancet Diabetes Endocrinol. 2021; 9: 293-303

  • 50.

    DPP-4 inhibitors could enhance the mortality of coronavirus illness 2019: a meta-analysis.

    PLoS One. 2021; 16e0251916

  • 51.
    • Abuhasira R
    • Ayalon-Dangur I
    • Zaslavsky N
    • et al.

    A randomized medical trial of linagliptin vs. normal of care in sufferers hospitalized with diabetes and COVID-19.

    Entrance Endocrinol. 2021; 12794382

  • 52.
    • Ohta N
    • Takahashi T
    • Mori T
    • et al.

    Hormonal modulation of prolyl endopeptidase and dipeptidyl peptidase IV actions within the mouse uterus and ovary.

    Acta Endocrinol (Copenh). 1992; 127: 262-266

  • 53.
    • Rajput MS
    • Sarkar PD
    • Nirmal NP

    Inhibition of DPP-4 exercise and neuronal atrophy with genistein attenuates neurological deficits induced by transient international cerebral ischemia and reperfusion in streptozotocin-induced diabetic mice.

    Irritation. 2017; 40: 623-635

  • 54.
    • Abdalla MA
    • Deshmukh H
    • Atkin S
    • Sathyapalan T

    The potential function of incretin-based therapies for polycystic ovary syndrome: a story evaluation of the present proof.

    Ther Adv Endocrinol Metab. 2021; 12 ()

  • 55.
    • Kim SC
    • Schneeweiss S
    • Glynn RJ
    • Doherty M
    • Goldfine AB
    • Solomon DH

    Dipeptidyl peptidase-4 inhibitors in kind 2 diabetes could scale back the chance of autoimmune ailments: a population-based cohort research.

    Ann Rheum Dis. 2015; 74: 1968-1975

  • 56.
    • Yazbeck R
    • Jaenisch SE
    • Abbott CA

    Dipeptidyl peptidase 4 inhibitors: functions in innate immunity?.

    Biochem Pharmacol. 2021; 188114517

  • 57.

    Intercourse variations in immune responses.

    Science. 2021; 371: 347-348

  • 58.
    • Ou T
    • Mou H
    • Zhang L
    • Ojha A
    • Choe H
    • Farzan M

    Hydroxychloroquine-mediated inhibition of SARS-CoV-2 entry is attenuated by TMPRSS2.

    PLoS Pathog. 2021; 17e1009212

  • 59.
    • Hoffmann M
    • Kleine-Weber H
    • Schroeder S
    • et al.

    SARS-CoV-2 cell entry is dependent upon ACE2 and TMPRSS2 and is blocked by a clinically confirmed protease inhibitor.

    Cell. 2020; 181: 271-280

  • 60.
    • Schuler BA
    • Habermann AC
    • Plosa EJ
    • et al.

    Age-determined expression of priming protease TMPRSS2 and localization of SARS-CoV-2 in lung epithelium.

    J Clin Make investments. 2021; 131140766

  • 61.
    • Okwan-Duodu D
    • Lim E-C
    • You S
    • Engman DM

    TMPRSS2 exercise could mediate intercourse variations in COVID-19 severity.

    Sign Transduct Goal Ther. 2021; 6: 100

  • 62.
    • Samuel RM
    • Majd H
    • Richter MN
    • Ghazizadeh Z
    • Zekavat SM
    • Navickas A
    • et al.

    Androgen signaling regulates SARS-CoV-2 receptor ranges and is related to extreme COVID-19 signs in males.

    Cell Stem Cell. 2020; 27: 876-889

  • 63.
    • Asselta R
    • Paraboschi EM
    • Mantovani A
    • Duga S

    ACE2 and TMPRSS2 variants and expression as candidates to intercourse and nation variations in COVID-19 severity in Italy.

    Growing old (Albany NY). 2020; 12: 10087-10098

  • 64.
    • Leach DA
    • Mohr A
    • Giotis ES
    • et al.

    The antiandrogen enzalutamide downregulates TMPRSS2 and reduces mobile entry of SARS-CoV-2 in human lung cells.

    Nat Commun. 2021; 124068

  • 65.
    • Gunst JD
    • Staerke NB
    • Pahus MH
    • et al.

    Efficacy of the TMPRSS2 inhibitor camostat mesilate in sufferers hospitalized with Covid-19 —a double-blind randomized managed trial.

    EClinicalMedicine. 2021; 35100849

  • 66.

    Intercourse variations within the hypothalamic-pituitary-adrenal axis’ response to emphasize: an necessary function for gonadal hormones.

    Neuropsychopharmacology. 2019; 44: 45-58

  • 67.

    Gonadal steroid hormones and the hypothalamo-pituitary-adrenal axis.

    Entrance Neuroendocrinol. 2014; 35: 197-220

  • 68.
    • Kanczkowski W
    • Evert Ok
    • Stadtmüller M
    • et al.

    COVID-19 targets human adrenal glands.

    Lancet Diabetes Endocrinol. 2021;

  • 69.
    • Horby P
    • Lim WS
    • Emberson JR
    • et al.

    Dexamethasone in hospitalized sufferers with Covid-19.

    N Engl J Med. 2021; 384: 693-704

  • 70.
    • Águas R
    • Mahdi A
    • Shretta R
    • Horby P
    • Landray M
    • White L

    Potential well being and financial impacts of dexamethasone therapy for sufferers with COVID-19.

    Nat Commun. 2021; 12: 1-8

  • 71.
    • Ranjbar Ok
    • Moghadami M
    • Mirahmadizadeh A
    • et al.

    Methylprednisolone or dexamethasone, which one is superior corticosteroid within the therapy of hospitalized COVID-19 sufferers: a triple-blinded randomized managed trial.

    BMC Infect Dis. 2021; 21: 1-8

  • 72.
    • Da Pozzo E
    • Giacomelli C
    • Cavallini C
    • Martini C

    Cytokine secretion responsiveness of lymphomonocytes following cortisol cell publicity: intercourse variations.

    PLoS One. 2018; 13e0200924

  • 73.
    • Ghandehari S
    • Matusov Y
    • Pepkowitz S
    • et al.

    Progesterone along with normal of care vs normal of care alone within the therapy of males hospitalized with average to extreme COVID-19: a randomized, managed pilot trial.

    Chest. 2021; 160: 74-84

  • 74.
    • Montopoli M
    • Zumerle S
    • Vettor R
    • et al.

    Androgen-deprivation therapies for prostate most cancers and threat of an infection by SARS-CoV-2: a population-based research (N = 4532).

    Ann Oncol. 2020; 31: 1040-1045

  • 75.
    • Goren A
    • Wambier CG
    • Herrera S
    • et al.

    Anti-androgens could defend towards extreme COVID-19 outcomes: outcomes from a potential cohort research of 77 hospitalized males.

    J Eur Acad Dermatol Venereol. 2021; 35: e13-e15

  • 76.
    • Dambha-Miller H
    • Hinton W
    • Pleasure M
    • Feher M
    • de Lusignan S

    Mortality in COVID-19 amongst girls on hormone substitute remedy or mixed oral contraception: a cohort research.

    medRxiv. 2021; ()

  • 77.

    Menopause transition: a golden age to stop heart problems.

    Lancet Diabetes Endocrinol. 2021; 9: 135-137

  • 78.
    • Okpechi SC
    • Fong JT
    • Gill SS
    • et al.

    World intercourse disparity of COVID-19: a descriptive evaluation of intercourse hormones and consideration for the potential therapeutic use of hormone substitute remedy in older adults.

    Growing old Dis. 2021; 12: 671-683

  • 79.
    • Rastrelli G
    • Di Stasi V
    • Inglese F
    • et al.

    Low testosterone ranges predict medical antagonistic outcomes in SARS-CoV-2 pneumonia sufferers.

    Andrology. 2021; 9: 88-98

  • 80.
    • Dhindsa S
    • Zhang N
    • McPhaul MJ
    • et al.

    Affiliation of circulating intercourse hormones with irritation and illness severity in sufferers with COVID-19.

    JAMA Netw Open. 2021; 4e2111398

  • 81.
    • Mohamad N-V
    • Wong SK
    • Hasan WNW
    • et al.

    The connection between circulating testosterone and inflammatory cytokines in males.

    Growing old Male. 2018;

  • 82.
    • Wu Y-H
    • Tseng C-P
    • Cheng M-L
    • Ho H-Y
    • Shih S-R
    • Chiu DT-Y

    Glucose-6-phosphate dehydrogenase deficiency enhances human coronavirus 229E an infection.

    J Infect Dis. 2008; 197: 812-816

  • 83.
    • Ackermann M
    • Verleden SE
    • Kuehnel M
    • et al.

    Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid-19.

    N Engl J Med. 2020; 383: 120-128

  • 84.
    • Heymann AD
    • Cohen Y
    • Chodick G

    Glucose-6-phosphate dehydrogenase deficiency and sort 2 diabetes.

    Diabetes care. 2012; 35: e58

  • 85.

    Alert to US physicians: DHEA, extensively used as an OTC androgen complement, could exacerbate COVID-19.

    Endocr Relat Most cancers. 2021; 28: R47-R53

  • 86.
    • Di Toro F
    • Gjoka M
    • Di Lorenzo G
    • et al.

    Affect of COVID-19 on maternal and neonatal outcomes: a scientific evaluation and meta-analysis.

    Clin Microbiol Infect. 2021; 27: 36-46

  • 87.
    • Ellington S
    • Strid P
    • Tong VT
    • et al.

    Traits of ladies of reproductive age with laboratory-confirmed SARS-CoV-2 an infection by being pregnant standing—United States, January 22–June 7, 2020.

    MMWR Morb Mortal Wkly Rep. 2020; 69: 769-775

  • 88.
    • Knight M
    • Bunch Ok
    • Vousden N
    • et al.

    Traits and outcomes of pregnant girls admitted to hospital with confirmed SARS-CoV-2 an infection in UK: nationwide inhabitants based mostly cohort research.

    BMJ. 2020; 369m2107

  • 89.
    • Wastnedge EAN
    • Reynolds RM
    • van Boeckel SR
    • et al.

    Being pregnant and COVID-19.

    Physiol Rev. 2021; 101: 303-318

  • 90.
    • Adrielle Dos Santos L
    • Filho PGG
    • Silva AMF
    • et al.

    Recurrent COVID-19 together with proof of reinfection and enhanced severity in thirty Brazilian healthcare staff.

    J Infect. 2021; 82: 399-406

  • 91.
    • Abdelrahman MM
    • Abd-Elrahman NM
    • Bakheet TM

    Persistence of signs after enchancment of acute COVID19 an infection, a longitudinal research.

    J Med Virol. 2021; 93: 5942-5946

  • 92.
    • Klein SL
    • Pekosz A
    • Park H-S
    • et al.

    Intercourse, age, and hospitalization drive antibody responses in a COVID-19 convalescent plasma donor inhabitants.

    J Clin Make investments. 2020; 130: 6141-6150

  • 93.
    • Galasso V
    • Pons V
    • Profeta P
    • Becher M
    • Brouard S
    • Foucault M

    Gender variations in COVID-19 attitudes and conduct: panel proof from eight nations.

    Proc Natl Acad Sci USA. 2020; 117: 27285-27291

  • 94.
    • Reisch T
    • Heiler G
    • Harm J
    • Klimek P
    • Hanbury A
    • Thurner S

    Behavioral gender variations are bolstered throughout the COVID-19 disaster.

    Sci Rep. 2021; 1119241

  • 95.

    What reinfections imply for COVID-19.

    Lancet Infect Dis. 2021; 21: 3-5

  • 96.
    • Van Elslande J
    • Vermeersch P
    • Vandervoort Ok
    • et al.

    Symptomatic extreme acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfection by a phylogenetically distinct pressure.

    Clin Infect Dis. 2021; 73: 354-356

  • 97.
    • Pulliam JR
    • van Schalkwyk C
    • Govender N
    • et al.

    Elevated threat of SARS-CoV-2 reinfection related to emergence of the Omicron variant in South Africa.

    medRxiv. 2021; ()

  • 98.

    How dangerous is Omicron? What scientists know to date.

    Nature. 2021; 600: 197-199

  • 99.
    • Cavanaugh AM
    • Spicer KB
    • Thoroughman D
    • Glick C
    • Winter Ok

    Decreased threat of reinfection with SARS-CoV-2 after COVID-19 vaccination—Kentucky, Could–June 2021.

    MMWR Morb Mortal Wkly Rep. 2021; 70: 1081-1083

  • 100.
    • Klein SL
    • Jedlicka A
    • Pekosz A

    The Xs and Y of immune responses to viral vaccines.

    Lancet Infect Dis. 2010; 10: 338-349

  • 101.
    • Muir Ok-L
    • Kallam A
    • Koepsell SA
    • Gundabolu Ok

    Thrombotic thrombocytopenia after Ad26. COV2. S vaccination.

    N Engl J Med. 2021; 384: 1964-1965

  • 102.
    • Greinacher A
    • Thiele T
    • Warkentin TE
    • Weisser Ok
    • Kyrle PA
    • Eichinger S

    Thrombotic thrombocytopenia after ChAdOx1 nCov-19 vaccination.

    N Engl J Med. 2021; 384: 2092-2101

  • 103.

    SARS-CoV-2 Vaccine-induced immune thrombotic thrombocytopenia.

    N Engl J Med. 2021; 384: 2254-2256

  • 104.
    • Shay DK
    • Shimabukuro TT
    • DeStefano F

    Myocarditis occurring after immunization with mRNA-based COVID-19 vaccines.

    JAMA Cardiol. 2021; 6: 1115-1117

  • 105.
    • Rosenblum HG
    • Hadler SC
    • Moulia D
    • et al.

    Use of COVID-19 vaccines after experiences of antagonistic occasions amongst grownup recipients of Janssen (Johnson & Johnson) and mRNA COVID-19 vaccines (Pfizer-BioNTech and Moderna): replace from the Advisory Committee on Immunization Practices—United States, July 2021.

    MMWR Morb Mortal Wkly Rep. 2021; 70: 1094-1099

  • 106.
    • Hacisuleyman E
    • Hale C
    • Saito Y
    • et al.

    Vaccine breakthrough infections with SARS-CoV-2 variants.

    N Engl J Med. 2021; 384: 2212-2218

  • 107.
    • CDC COVID-19 Vaccine Breakthrough Case Investigations Crew

    COVID-19 vaccine breakthrough infections reported to CDC—United States, January 1–April 30, 2021.

    MMWR Morb Mortal Wkly Rep. 2021; 70: 792-793

  • 108.
    • Huang C
    • Huang L
    • Wang Y
    • et al.

    6-month penalties of COVID-19 in sufferers discharged from hospital: a cohort research.

    Lancet. 2021; 397: 220-232

  • 109.
    • Ortega-Hernandez OD
    • Shoenfeld Y

    An infection, vaccination, and autoantibodies in continual fatigue syndrome, trigger or coincidence?.

    Ann N Y Acad Sci. 2009; 1173: 600-609

  • 110.
    • Appel S
    • Chapman J
    • Shoenfeld Y

    An infection and vaccination in continual fatigue syndrome: delusion or actuality?.

    Autoimmunity. 2007; 40: 48-53

  • 111.

    Immune determinants of COVID-19 illness presentation and severity.

    Nat Med. 2021; 27: 28-33

  • 112.
    • Seeßle J
    • Waterboer T
    • Hippchen T
    • et al.

    Persistent signs in grownup sufferers one yr after COVID-19: a potential cohort research.

    Clin Infect Dis. 2021; ciab611

  • 113.
    • Gebhard CE
    • Suetsch C
    • Bengs S
    • et al.

    Intercourse-and gender-specific threat elements of post-COVID-19 syndrome: a population-based cohort research in Switzerland.

    medRxiv. 2021; ()

  • 114.
    • Sudre CH
    • Murray B
    • Varsavsky T
    • et al.

    Attributes and predictors of lengthy COVID.

    Nat Med. 2021; 27: 626-631

  • 115.
    • Hoffman KW
    • Lee JJ
    • Foster GA
    • Krysztof D
    • Stramer SL
    • Lim JK

    Intercourse variations in cytokine manufacturing following West Nile virus an infection: Implications for symptom manifestation.

    Pathog Dis. 2019; 77ftz016

  • 116.
    • Pandey JP
    • Fudenberg HH
    • Ainsworth SK
    • Loadholt CB

    Autoantibodies in wholesome topics of various age teams.

    Mech Ageing Dev. 1979; 10: 399-404

  • 117.
    • Williams AJ
    • Norcross AJ
    • Dix RJ
    • Gillespie KM
    • Gale EA
    • Bingley PJ

    The prevalence of insulin autoantibodies on the onset of kind 1 diabetes is greater in males than females throughout adolescence.

    Diabetologia. 2003; 46: 1354-1356

  • 118.

    Rogue antibodies may very well be driving extreme COVID-19.

    Nature. 2021; 590: 29-31

  • 119.
    • Bornstein SR
    • Voit-Bak Ok
    • Donate T
    • et al.

    Continual post-COVID-19 syndrome and continual fatigue syndrome: Is there a job for extracorporeal apheresis?.

    Mol Psychiatry. 2021; ()

  • 120.
    • Leynaert B
    • Sunyer J
    • Garcia-Esteban R
    • et al.

    Gender variations in prevalence, prognosis and incidence of allergic and non-allergic bronchial asthma: a population-based cohort.

    Thorax. 2012; 67: 625-631

  • 121.
    • Maccio U
    • Zinkernagel AS
    • Shambat SM
    • et al.

    SARS-CoV-2 results in a small vessel endotheliitis within the coronary heart.

    EBioMedicine. 2021; 63103182