Does Vitamin D2 or D3 Benefit or Damage Muscles?

A consensus of printed literature did not assistance vitamin D supplementation for promotion of muscle…

Does Vitamin D2 or D3 Benefit or Damage Muscles?

A consensus of printed literature did not assistance vitamin D supplementation for promotion of muscle wellness and indicated that supplementation could cause adverse results in some conditions. These results, from a systematic critique and meta-evaluation, had been printed in the Journal of Bone Mineral Research.

Researchers from Aarhus University Hospital in Denmark done a search in October 2020 of on the net medical literature for experiments of the impact of vitamin D supplementation  on muscle mass overall health and perform making use of research terms these types of as ‘muscle strength’, ‘muscle function’ and ‘vitamin D’, amongst others.

A overall of 54 research randomized management trials comprising 8747 individuals were included in this evaluation. Individuals ended up dominated by postmenopausal females 3 of the scientific tests recruited only men and 3 recruited only kids. Muscle overall health was most generally assessed by handgrip strength (n=35), knee extension (n=20), and timed up and go (n=19) exams. Vitamin D supplementation was administered for ³26 weeks in 33 of the research.

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Vitamin D supplementation was uncovered to significantly enhance up and go time amongst 5223 members (necessarily mean variance, .15 95{6654ab549aea683dfb163c18f2e935eca578ab77e61967d7a8b1932c06e74d91} CI, .03-.26 P =.01) and to noticeably reduce knee flexion between 765 individuals (signify distinction, -3.33 95{6654ab549aea683dfb163c18f2e935eca578ab77e61967d7a8b1932c06e74d91} CI, -6.63 to -.03 P =.05).

No major influence was reported for shorter bodily functionality battery, chair growing check, 6-moment walking distance, handgrip, elbow extension, elbow flexion, knee extension, or whole lean mass.

Among the the subset of experiments which employed differing doses of vitamin D, no sizeable influence concerning large and very low doses had been observed vs placebo. Likewise, co-supplementation with calcium, stratifying vitamin D2 from D3, or stratifying scientific studies on date of publication did not change the all round findings.

Scientists acknowledged their study may have been limited by the point that supplementation was administered for ≥6 months in the the greater part of studies, nor did they incorporate clients with extreme vitamin D deficiency.  It remains unclear whether differing results would be noticed with long-time period publicity.

Furthermore, these information did not assistance the use of supplemental vitamin D2 or D3 with or devoid of calcium, as there was minimal evidence for enhanced muscle mass health and fitness. Some proof advised that supplementation could in truth destruction muscle wellness by lessening knee flexion.

“Given the massive public curiosity in vitamin D supplementation, we will need to be informed of uncritical use of vitamin D,” the researchers reported. “Identifying safe repletion regimens is warranted.”


Bislev LS, Grove-Laugesen D, Rejnmark L. Vitamin D and muscle health: a systematic review and meta-analysis of randomized placebo-managed trials. J Bone Miner Res. 202136(9):1651-1660. doi:10.1002/jbmr.4412